Azide-to-diazo reaction unlocks safer path to versatile nitrogen-rich compounds

Mississippi State University biologist Matthew W. Brown is part of an international research team whose latest findings, published this spring in the Proceedings of the National Academy of Sciences, are reshaping scientific understanding of how parasitic organisms evolve and ultimately spread disease.

Mechanochemistry is a growing field for chemical reactions that proceed in the solid state in the absence, or with minuscule amounts, of solvent added. For decades, solvents have been considered conventional for the progression of modern chemistry; nonetheless, researchers are increasingly demonstrating that mechanochemistry can synthesize complex molecules more effectively. With more progress, mechanochemistry could alleviate solvent-related environmental and financial burdens in chemical indus

Recent research published in Communications Biology marks an advance in structural biology by enhancing understanding of protein regulation mechanisms in Mycobacterium tuberculosis (Mtb), a global health threat. The team led by the University of Melbourne combined several advanced techniques at the Australian Synchrotron and the National Deuteration Facility to reveal the hidden allosteric mechanism that activates a key enzyme, ICL2.