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New metal-free biaryl method could simplify drug and materials synthesis

New metal-free biaryl method could simplify drug and materials synthesis
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Researchers at the Institute of Science Tokyo have developed a simple and efficient method for synthesizing polyfunctionalized biaryls without transition-metal catalysts or complex multistep prefunctionalization. Through an innovative substrate design strategy, the researchers achieved a benzidine-type sigmatropic rearrangement of nitroarenes that efficiently produces the desired biaryls in high y

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